Drug interactions
Maraviroc + Metolazone
Severity: Moderate
Maraviroc and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc can cause postural hypotension, and use with a diuretic that reduces blood volume may increase the risk of dizziness and falls. The effect is mainly seen in patients with renal impairment or those on other blood pressure-lowering drugs.
What this interaction means in plain words
Maraviroc and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Metolazone belongs to Cardiovascular.
Why it happens
Additive orthostatic hypotensive effects, with diuretic-related volume depletion.
What to do
Monitor blood pressure including orthostatic readings, especially with renal impairment. Reduce the diuretic dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Metolazone?
MediHelp rates the interaction as moderate. Maraviroc and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc can cause postural hypotension, and use with a diuretic that reduces blood volume may increase the risk of dizziness and falls. The effect is mainly seen in patients with renal impairment or those on other blood pressure-lowering drugs.
How serious is the interaction between Maraviroc and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings, especially with renal impairment. Reduce the diuretic dose if symptomatic hypotension develops.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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