Drug interactions
Medroxyprogesterone + Nevirapine
Severity: Minor
Medroxyprogesterone and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine has little effect on depot medroxyprogesterone acetate exposure in studies, and contraceptive efficacy appears maintained. Oral formulations used for other indications might theoretically be less effective.
What this interaction means in plain words
Medroxyprogesterone and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, which contributes to medroxyprogesterone metabolism, though the effect is small.
What to do
Depot injections can be used without dose change; monitor response when oral medroxyprogesterone is used for therapeutic indications.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Nevirapine?
MediHelp rates the interaction as minor. Medroxyprogesterone and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine has little effect on depot medroxyprogesterone acetate exposure in studies, and contraceptive efficacy appears maintained. Oral formulations used for other indications might theoretically be less effective.
How serious is the interaction between Medroxyprogesterone and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Depot injections can be used without dose change; monitor response when oral medroxyprogesterone is used for therapeutic indications.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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