Drug interactions
Medroxyprogesterone + Stiripentol
Severity: Moderate
Medroxyprogesterone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP enzymes, so medroxyprogesterone exposure could rise or fall. The net effect is unpredictable and contraceptive efficacy could be reduced.
What this interaction means in plain words
Medroxyprogesterone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Medroxyprogesterone belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters progestin metabolism unpredictably.
What to do
Monitor for loss of effect (breakthrough bleeding) or progestogenic adverse effects. Consider supplementary non-hormonal contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Stiripentol
Frequently asked questions
Can I take Medroxyprogesterone with Stiripentol?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP enzymes, so medroxyprogesterone exposure could rise or fall. The net effect is unpredictable and contraceptive efficacy could be reduced.
How serious is the interaction between Medroxyprogesterone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of effect (breakthrough bleeding) or progestogenic adverse effects. Consider supplementary non-hormonal contraception.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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