Drug interactions
Melatonin + Ticlopidine
Severity: Minor
Melatonin and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has no well-established effect on platelet function or coagulation at usual doses, and the claimed effect on prothrombin time is inconsistent. A clinically relevant interaction with ticlopidine is not supported.
What this interaction means in plain words
Melatonin and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Ticlopidine belongs to Cardiovascular.
Why it happens
No established mechanism; a possible minor effect on coagulation is speculative.
What to do
No action beyond awareness; report any unusual bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Ticlopidine?
MediHelp rates the interaction as minor. Melatonin and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has no well-established effect on platelet function or coagulation at usual doses, and the claimed effect on prothrombin time is inconsistent. A clinically relevant interaction with ticlopidine is not supported.
How serious is the interaction between Melatonin and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond awareness; report any unusual bleeding.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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