Drug interactions
Methamphetamine + Prochlorperazine
Severity: Moderate
Methamphetamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopamine blockade by phenothiazines can blunt the stimulant effects of methamphetamine, and the combination may add to cardiovascular strain or arrhythmia risk in predisposed patients.
What this interaction means in plain words
Methamphetamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopaminergic pathways, with possible additive cardiac effects.
What to do
Monitor for reduced stimulant efficacy and for palpitations or ECG changes in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Methamphetamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopamine blockade by phenothiazines can blunt the stimulant effects of methamphetamine, and the combination may add to cardiovascular strain or arrhythmia risk in predisposed patients.
How serious is the interaction between Methamphetamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced stimulant efficacy and for palpitations or ECG changes in patients with cardiac disease.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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