Drug interactions
Methylprednisolone + Tucatinib
Severity: Moderate
Methylprednisolone and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and may increase methylprednisolone exposure. This could intensify corticosteroid adverse effects such as hyperglycemia, fluid retention and adrenal suppression.
What this interaction means in plain words
Methylprednisolone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, decreasing methylprednisolone metabolism.
What to do
Monitor for corticosteroid excess and reduce the methylprednisolone dose if needed, particularly with prolonged therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Methylprednisolone with Tucatinib?
MediHelp rates the interaction as moderate. Methylprednisolone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a moderate CYP3A inhibitor and may increase methylprednisolone exposure. This could intensify corticosteroid adverse effects such as hyperglycemia, fluid retention and adrenal suppression.
How serious is the interaction between Methylprednisolone and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and reduce the methylprednisolone dose if needed, particularly with prolonged therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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