Drug interactions
Metoclopramide + Oxycodone
Severity: Moderate
Metoclopramide and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxycodone reduces gastrointestinal motility, countering metoclopramide's prokinetic effect, and both drugs add to sedation. Metoclopramide may also speed absorption of oral opioids.
What this interaction means in plain words
Metoclopramide and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Oxycodone belongs to Musculoskeletal.
Why it happens
Opposing gut motility effects and additive CNS depression.
What to do
Monitor sedation and respiratory rate, particularly at initiation and dose changes. Reassess prokinetic benefit if constipation or gastroparesis symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Metoclopramide with Oxycodone?
MediHelp rates the interaction as moderate. Metoclopramide and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxycodone reduces gastrointestinal motility, countering metoclopramide's prokinetic effect, and both drugs add to sedation. Metoclopramide may also speed absorption of oral opioids.
How serious is the interaction between Metoclopramide and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, particularly at initiation and dose changes. Reassess prokinetic benefit if constipation or gastroparesis symptoms persist.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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