Drug interactions
Metoclopramide + Pregabalin
Severity: Minor
Metoclopramide and Pregabalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause dizziness, somnolence and impaired concentration. Together these effects may be additive, especially in older or renally impaired patients, since both are renally eliminated.
What this interaction means in plain words
Metoclopramide and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoclopramide belongs to Gastrointestinal Tract; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depression; both drugs are cleared by the kidney.
What to do
Counsel on sedation and reduce doses in renal impairment. Monitor older patients for confusion and falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Pregabalin
Frequently asked questions
Can I take Metoclopramide with Pregabalin?
MediHelp rates the interaction as minor. Metoclopramide and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause dizziness, somnolence and impaired concentration. Together these effects may be additive, especially in older or renally impaired patients, since both are renally eliminated.
How serious is the interaction between Metoclopramide and Pregabalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and reduce doses in renal impairment. Monitor older patients for confusion and falls.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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