Drug interactions
Metoclopramide + Sevoflurane
Severity: Minor
Metoclopramide and Sevoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may add to the sedative effect of inhaled anesthetics and can reduce anesthetic requirements. This is typically manageable in a monitored perioperative setting.
What this interaction means in plain words
Metoclopramide and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoclopramide belongs to Gastrointestinal Tract; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive central nervous system depression; no clear pharmacokinetic interaction.
What to do
Titrate anesthetic depth to clinical response and monitor hemodynamics and emergence.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Sevoflurane
Frequently asked questions
Can I take Metoclopramide with Sevoflurane?
MediHelp rates the interaction as minor. Metoclopramide and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide may add to the sedative effect of inhaled anesthetics and can reduce anesthetic requirements. This is typically manageable in a monitored perioperative setting.
How serious is the interaction between Metoclopramide and Sevoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate anesthetic depth to clinical response and monitor hemodynamics and emergence.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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