Drug interactions
Metoclopramide + Trimipramine
Severity: Moderate
Metoclopramide and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants and metoclopramide both can cause extrapyramidal effects, sedation and QT prolongation, and metoclopramide has been linked to serotonin toxicity with serotonergic antidepressants. Trimipramine's CYP2D6 involvement may also modestly affect metoclopramide exposure.
What this interaction means in plain words
Metoclopramide and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Trimipramine belongs to Central Nervous System.
Why it happens
Additive dopamine antagonism, CNS depression and serotonergic effects, with possible CYP2D6 competition.
What to do
Monitor for extrapyramidal symptoms, sedation, serotonin toxicity and ECG changes where risk factors exist. Use the lowest effective metoclopramide dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Metoclopramide with Trimipramine?
MediHelp rates the interaction as moderate. Metoclopramide and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants and metoclopramide both can cause extrapyramidal effects, sedation and QT prolongation, and metoclopramide has been linked to serotonin toxicity with serotonergic antidepressants. Trimipramine's CYP2D6 involvement may also modestly affect metoclopramide exposure.
How serious is the interaction between Metoclopramide and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation, serotonin toxicity and ECG changes where risk factors exist. Use the lowest effective metoclopramide dose for the shortest time.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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