Drug interactions
Metoclopramide + Zonisamide
Severity: Minor
Metoclopramide and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Additive drowsiness, dizziness and cognitive effects may occur. No significant pharmacokinetic interaction is established.
What this interaction means in plain words
Metoclopramide and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoclopramide belongs to Gastrointestinal Tract; Zonisamide belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel on sedation and monitor for CNS adverse effects after starting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Metoclopramide with Zonisamide?
MediHelp rates the interaction as minor. Metoclopramide and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Additive drowsiness, dizziness and cognitive effects may occur. No significant pharmacokinetic interaction is established.
How serious is the interaction between Metoclopramide and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and monitor for CNS adverse effects after starting either drug.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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