Drug interactions
Midodrine + Prochlorperazine
Severity: Moderate
Midodrine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The interaction is poorly defined. Prochlorperazine causes alpha-blockade and orthostatic hypotension that may oppose midodrine's pressor effect, and both can influence cardiovascular function.
What this interaction means in plain words
Midodrine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition between alpha-adrenergic blockade and alpha-1 agonism.
What to do
Monitor blood pressure, including supine and standing readings, and adjust the midodrine dose if its effect is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Prochlorperazine?
MediHelp rates the interaction as moderate. Midodrine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The interaction is poorly defined. Prochlorperazine causes alpha-blockade and orthostatic hypotension that may oppose midodrine's pressor effect, and both can influence cardiovascular function.
How serious is the interaction between Midodrine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine and standing readings, and adjust the midodrine dose if its effect is reduced.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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