Drug interactions
Mirtazapine + Propofol
Severity: Moderate
Mirtazapine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol and mirtazapine both depress the central nervous system, so sedation and recovery time may be prolonged during anesthesia or procedural sedation. Both drugs have also been associated with QT prolongation, which adds a small arrhythmia risk in susceptible patients.
What this interaction means in plain words
Mirtazapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression (GABA-A potentiation plus H1 antagonism) and additive QT-prolonging potential.
What to do
Titrate propofol to effect with a possible lower dose requirement and monitor sedation depth and respiratory status. Check electrolytes and monitor ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Mirtazapine with Propofol?
MediHelp rates the interaction as moderate. Mirtazapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol and mirtazapine both depress the central nervous system, so sedation and recovery time may be prolonged during anesthesia or procedural sedation. Both drugs have also been associated with QT prolongation, which adds a small arrhythmia risk in susceptible patients.
How serious is the interaction between Mirtazapine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with a possible lower dose requirement and monitor sedation depth and respiratory status. Check electrolytes and monitor ECG in patients with other QT risk factors.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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