Drug interactions
Mitomycin + Vemurafenib
Severity: Moderate
Mitomycin and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may increase exposure to P-gp substrates such as mitomycin. This could heighten myelosuppression and other adverse effects, though specific data are limited.
What this interaction means in plain words
Mitomycin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitomycin belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-gp efflux, potentially increasing mitomycin exposure.
What to do
Monitor complete blood counts and signs of mitomycin toxicity, and reduce the mitomycin dose if excess toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Mitomycin with Vemurafenib?
MediHelp rates the interaction as moderate. Mitomycin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may increase exposure to P-gp substrates such as mitomycin. This could heighten myelosuppression and other adverse effects, though specific data are limited.
How serious is the interaction between Mitomycin and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of mitomycin toxicity, and reduce the mitomycin dose if excess toxicity occurs.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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