Drug interactions
Modafinil + Pacritinib
Severity: Moderate
Modafinil and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is a CYP3A4 substrate, and modafinil is a weak-to-moderate CYP3A4 inducer. Reduced pacritinib concentrations may lessen its efficacy in myelofibrosis.
What this interaction means in plain words
Modafinil and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Pacritinib belongs to Oncology.
Why it happens
Modafinil induces CYP3A4, increasing pacritinib metabolism and lowering exposure.
What to do
Monitor spleen response and blood counts, and consider an alternative to modafinil if efficacy declines. Avoid strong inducers with pacritinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Modafinil and Pacritinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Modafinil
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Modafinil with Pacritinib?
MediHelp rates the interaction as moderate. Modafinil and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib is a CYP3A4 substrate, and modafinil is a weak-to-moderate CYP3A4 inducer. Reduced pacritinib concentrations may lessen its efficacy in myelofibrosis.
How serious is the interaction between Modafinil and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spleen response and blood counts, and consider an alternative to modafinil if efficacy declines. Avoid strong inducers with pacritinib.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
