Drug interactions
Modafinil + Posaconazole
Severity: Minor
Modafinil and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is partly metabolized by CYP3A4, so posaconazole may raise its concentrations. Modafinil also weakly induces CYP3A4, which could lower posaconazole exposure slightly, though this is not well established. Clinical effects are likely modest.
What this interaction means in plain words
Modafinil and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by posaconazole reduces modafinil clearance.
What to do
Monitor for modafinil adverse effects such as insomnia, anxiety, headache or palpitations and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Posaconazole?
MediHelp rates the interaction as minor. Modafinil and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is partly metabolized by CYP3A4, so posaconazole may raise its concentrations. Modafinil also weakly induces CYP3A4, which could lower posaconazole exposure slightly, though this is not well established. Clinical effects are likely modest.
How serious is the interaction between Modafinil and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects such as insomnia, anxiety, headache or palpitations and reduce the dose if they occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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