Drug interactions
Modafinil + Prochlorperazine
Severity: Minor
Modafinil and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine's sedative and dopamine-blocking effects may oppose modafinil's wake-promoting action, reducing its benefit.
What this interaction means in plain words
Modafinil and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of wakefulness through dopamine and histamine receptor blockade.
What to do
Monitor for reduced alertness and reassess the need for the antiemetic if modafinil efficacy declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Prochlorperazine?
MediHelp rates the interaction as minor. Modafinil and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prochlorperazine's sedative and dopamine-blocking effects may oppose modafinil's wake-promoting action, reducing its benefit.
How serious is the interaction between Modafinil and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced alertness and reassess the need for the antiemetic if modafinil efficacy declines.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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