Drug interactions
Momelotinib + Sofosbuvir
Severity: Minor
Momelotinib and Sofosbuvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP and may modestly increase sofosbuvir absorption. The expected change is small and unlikely to matter clinically.
What this interaction means in plain words
Momelotinib and Sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Momelotinib belongs to Oncology; Sofosbuvir belongs to Anti Virals.
Why it happens
Intestinal BCRP inhibition by momelotinib, not protein-binding competition.
What to do
No empiric dose change is needed. Monitor tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Sofosbuvir?
MediHelp rates the interaction as minor. Momelotinib and Sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Momelotinib inhibits BCRP and may modestly increase sofosbuvir absorption. The expected change is small and unlikely to matter clinically.
How serious is the interaction between Momelotinib and Sofosbuvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor tolerability.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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