Drug interactions
Montelukast + Nevirapine
Severity: Minor
Montelukast and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces hepatic enzymes and could in theory lower montelukast exposure. Because montelukast has a wide therapeutic margin and is cleared mainly by CYP2C8 and CYP2C9, any loss of effect is likely small.
What this interaction means in plain words
Montelukast and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Montelukast belongs to Respiratory; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4 and CYP2B6, which may modestly increase montelukast metabolism.
What to do
No dose change is needed routinely. Check asthma or rhinitis control if symptoms worsen after nevirapine is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Montelukast with Nevirapine?
MediHelp rates the interaction as minor. Montelukast and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine induces hepatic enzymes and could in theory lower montelukast exposure. Because montelukast has a wide therapeutic margin and is cleared mainly by CYP2C8 and CYP2C9, any loss of effect is likely small.
How serious is the interaction between Montelukast and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Check asthma or rhinitis control if symptoms worsen after nevirapine is started.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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