Drug interactions
Montelukast + Stiripentol
Severity: Minor
Montelukast and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on several CYP enzymes, so montelukast exposure could change in either direction. The net effect has not been well characterized and is probably small clinically.
What this interaction means in plain words
Montelukast and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Montelukast belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol variably inhibits and induces CYP3A4 and other CYP enzymes involved in montelukast metabolism; the net effect is uncertain.
What to do
Monitor for loss of asthma control or increased adverse effects such as neuropsychiatric symptoms. Adjust therapy according to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Montelukast with Stiripentol?
MediHelp rates the interaction as minor. Montelukast and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol has both inhibitory and inducing effects on several CYP enzymes, so montelukast exposure could change in either direction. The net effect has not been well characterized and is probably small clinically.
How serious is the interaction between Montelukast and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of asthma control or increased adverse effects such as neuropsychiatric symptoms. Adjust therapy according to clinical response.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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