Drug interactions
Nevirapine + Pacritinib
Severity: Major
Nevirapine and Pacritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower pacritinib exposure and reduce its benefit in myelofibrosis. Strong CYP3A4 inducers markedly reduce pacritinib exposure.
What this interaction means in plain words
Nevirapine and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nevirapine belongs to Anti Virals; Pacritinib belongs to Oncology.
Why it happens
CYP3A4 induction by nevirapine increases pacritinib metabolism.
What to do
Avoid concurrent use and choose another antiretroviral. If unavoidable, monitor spleen and symptom response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Nevirapine with Pacritinib?
MediHelp rates the interaction as major. Nevirapine and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine may lower pacritinib exposure and reduce its benefit in myelofibrosis. Strong CYP3A4 inducers markedly reduce pacritinib exposure.
How serious is the interaction between Nevirapine and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose another antiretroviral. If unavoidable, monitor spleen and symptom response.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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