Drug interactions
Nevirapine + Perampanel
Severity: Moderate
Nevirapine and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce perampanel concentrations and weaken seizure control. Strong enzyme-inducing antiseizure drugs markedly lower perampanel levels, and nevirapine may have a smaller similar effect.
What this interaction means in plain words
Nevirapine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Perampanel belongs to Central Nervous System.
Why it happens
Nevirapine induces CYP3A4, increasing perampanel clearance.
What to do
Monitor seizure frequency and titrate perampanel to clinical response. Reassess the dose if nevirapine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Nevirapine with Perampanel?
MediHelp rates the interaction as moderate. Nevirapine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce perampanel concentrations and weaken seizure control. Strong enzyme-inducing antiseizure drugs markedly lower perampanel levels, and nevirapine may have a smaller similar effect.
How serious is the interaction between Nevirapine and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and titrate perampanel to clinical response. Reassess the dose if nevirapine is started or stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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