Drug interactions
Nevirapine + Posaconazole
Severity: Moderate
Nevirapine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is a CYP3A4 inducer and may lower posaconazole concentrations, risking antifungal treatment failure. Posaconazole may in turn raise nevirapine levels, which could increase hepatotoxicity and rash.
What this interaction means in plain words
Nevirapine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Posaconazole belongs to Anti Fungals.
Why it happens
Nevirapine induces CYP3A4 and UDP-glucuronosyltransferase, while posaconazole inhibits CYP3A4.
What to do
Monitor posaconazole trough concentrations and clinical response, and watch liver enzymes and skin reactions. Adjust the antifungal regimen if levels are subtherapeutic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Posaconazole?
MediHelp rates the interaction as moderate. Nevirapine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is a CYP3A4 inducer and may lower posaconazole concentrations, risking antifungal treatment failure. Posaconazole may in turn raise nevirapine levels, which could increase hepatotoxicity and rash.
How serious is the interaction between Nevirapine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor posaconazole trough concentrations and clinical response, and watch liver enzymes and skin reactions. Adjust the antifungal regimen if levels are subtherapeutic.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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