Drug interactions
Nevirapine + Toremifene
Severity: Moderate
Nevirapine and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower toremifene serum concentrations by speeding its metabolism. This may reduce antiestrogen efficacy in breast cancer treatment.
What this interaction means in plain words
Nevirapine and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Toremifene belongs to Endocrine.
Why it happens
Nevirapine induces CYP3A4, which is the main metabolic pathway of toremifene.
What to do
Monitor for reduced oncologic response and consider a non-inducing antiretroviral. Dose adjustment of toremifene may be needed under specialist guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Nevirapine with Toremifene?
MediHelp rates the interaction as moderate. Nevirapine and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine can lower toremifene serum concentrations by speeding its metabolism. This may reduce antiestrogen efficacy in breast cancer treatment.
How serious is the interaction between Nevirapine and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced oncologic response and consider a non-inducing antiretroviral. Dose adjustment of toremifene may be needed under specialist guidance.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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