Drug interactions
Nevirapine + Ubrogepant
Severity: Moderate
Nevirapine and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is a CYP3A4 inducer and can lower ubrogepant exposure, which may reduce its effectiveness in treating acute migraine. Labeling recommends a dose adjustment when ubrogepant is combined with weak or moderate CYP3A4 inducers.
What this interaction means in plain words
Nevirapine and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Ubrogepant belongs to Central Nervous System.
Why it happens
Nevirapine induces hepatic and intestinal CYP3A4, increasing the metabolism of ubrogepant, a CYP3A4 substrate.
What to do
Use the higher ubrogepant dose per labeling for moderate or weak inducers (100 mg initial dose, with optional second dose of 100 mg). Monitor migraine response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Nevirapine with Ubrogepant?
MediHelp rates the interaction as moderate. Nevirapine and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is a CYP3A4 inducer and can lower ubrogepant exposure, which may reduce its effectiveness in treating acute migraine. Labeling recommends a dose adjustment when ubrogepant is combined with weak or moderate CYP3A4 inducers.
How serious is the interaction between Nevirapine and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the higher ubrogepant dose per labeling for moderate or weak inducers (100 mg initial dose, with optional second dose of 100 mg). Monitor migraine response.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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