Drug interactions
Nevirapine + Vilazodone
Severity: Moderate
Nevirapine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is metabolised mainly by CYP3A4, which nevirapine induces. Reduced vilazodone exposure may lead to loss of antidepressant effect.
What this interaction means in plain words
Nevirapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Vilazodone belongs to Central Nervous System.
Why it happens
Nevirapine induction of CYP3A4 increases vilazodone clearance.
What to do
Monitor for loss of antidepressant response and consider increasing the vilazodone dose, up to about twice the usual dose within labelled limits. Reduce back to the original dose if nevirapine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Nevirapine with Vilazodone?
MediHelp rates the interaction as moderate. Nevirapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone is metabolised mainly by CYP3A4, which nevirapine induces. Reduced vilazodone exposure may lead to loss of antidepressant effect.
How serious is the interaction between Nevirapine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response and consider increasing the vilazodone dose, up to about twice the usual dose within labelled limits. Reduce back to the original dose if nevirapine is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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