Drug interactions
Nintedanib + Ranolazine
Severity: Moderate
Nintedanib and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein and may raise nintedanib exposure, since nintedanib is a P-gp substrate. Higher nintedanib levels could increase gastrointestinal effects such as diarrhea and nausea, and hepatotoxicity.
What this interaction means in plain words
Nintedanib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nintedanib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine inhibits P-glycoprotein efflux, increasing absorption and reducing clearance of nintedanib.
What to do
Monitor for nintedanib adverse effects, especially diarrhea and liver enzyme elevations. Interrupt or reduce the nintedanib dose if these effects become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nintedanib and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Ranolazine?
MediHelp rates the interaction as moderate. Nintedanib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein and may raise nintedanib exposure, since nintedanib is a P-gp substrate. Higher nintedanib levels could increase gastrointestinal effects such as diarrhea and nausea, and hepatotoxicity.
How serious is the interaction between Nintedanib and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nintedanib adverse effects, especially diarrhea and liver enzyme elevations. Interrupt or reduce the nintedanib dose if these effects become troublesome.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
