Drug interactions
Omaveloxolone + Posaconazole
Severity: Major
Omaveloxolone and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized mainly by CYP3A4, so posaconazole can raise its exposure. This may increase adverse effects such as liver enzyme elevations and lipid changes.
What this interaction means in plain words
Omaveloxolone and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Omaveloxolone belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces omaveloxolone clearance.
What to do
Avoid if possible. If unavoidable, reduce the omaveloxolone dose per labeling, monitor liver tests, and discontinue if adverse effects emerge.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Posaconazole?
MediHelp rates the interaction as major. Omaveloxolone and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omaveloxolone is metabolized mainly by CYP3A4, so posaconazole can raise its exposure. This may increase adverse effects such as liver enzyme elevations and lipid changes.
How serious is the interaction between Omaveloxolone and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the omaveloxolone dose per labeling, monitor liver tests, and discontinue if adverse effects emerge.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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