Drug interactions
Ondansetron + Tepotinib
Severity: Minor
Ondansetron and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase exposure to P-gp substrates. Ondansetron is only a weak P-gp substrate, so any increase is likely small, though ondansetron has dose-related QT effects.
What this interaction means in plain words
Ondansetron and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Tepotinib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein by tepotinib may modestly increase ondansetron absorption.
What to do
No dose adjustment is usually needed. Monitor for adverse effects such as headache, constipation or QT symptoms, especially in patients with cardiac risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Ondansetron with Tepotinib?
MediHelp rates the interaction as minor. Ondansetron and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-glycoprotein and may increase exposure to P-gp substrates. Ondansetron is only a weak P-gp substrate, so any increase is likely small, though ondansetron has dose-related QT effects.
How serious is the interaction between Ondansetron and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for adverse effects such as headache, constipation or QT symptoms, especially in patients with cardiac risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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