Drug interactions
Ondansetron + Tucatinib
Severity: Minor
Ondansetron and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise ondansetron concentrations. Ondansetron is metabolised by several enzymes including CYP3A4, CYP1A2 and CYP2D6, so the overall effect is expected to be modest.
What this interaction means in plain words
Ondansetron and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibition of CYP3A4 may modestly reduce ondansetron clearance.
What to do
No empirical dose change is required. Monitor for dose-related adverse effects such as constipation, headache and QT changes in patients at cardiac risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Ondansetron with Tucatinib?
MediHelp rates the interaction as minor. Ondansetron and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits CYP3A4 and may raise ondansetron concentrations. Ondansetron is metabolised by several enzymes including CYP3A4, CYP1A2 and CYP2D6, so the overall effect is expected to be modest.
How serious is the interaction between Ondansetron and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required. Monitor for dose-related adverse effects such as constipation, headache and QT changes in patients at cardiac risk.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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