Drug interactions
Oteseconazole + Tenofovir alafenamide
Severity: Minor
Oteseconazole and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP and may modestly increase exposure to tenofovir alafenamide. Oteseconazole is used for limited periods in patients who cannot become pregnant, and a clinically significant effect is not expected.
What this interaction means in plain words
Oteseconazole and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oteseconazole belongs to Anti Fungals; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
BCRP inhibition by oteseconazole increasing absorption of tenofovir alafenamide.
What to do
No routine adjustment is needed. Monitor for tenofovir-related adverse effects, including renal changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Oteseconazole with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Oteseconazole and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oteseconazole inhibits BCRP and may modestly increase exposure to tenofovir alafenamide. Oteseconazole is used for limited periods in patients who cannot become pregnant, and a clinically significant effect is not expected.
How serious is the interaction between Oteseconazole and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for tenofovir-related adverse effects, including renal changes.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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