Drug interactions
Oxycodone + Perampanel
Severity: Moderate
Oxycodone and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel can cause dizziness, somnolence and impaired coordination, which may add to opioid CNS effects. Perampanel also has weak CYP3A4 induction at higher doses, which might modestly lower oxycodone levels.
What this interaction means in plain words
Oxycodone and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible weak CYP3A4 induction by perampanel.
What to do
Monitor for sedation, dizziness and falls, and check analgesic response, adjusting the oxycodone dose if necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Oxycodone with Perampanel?
MediHelp rates the interaction as moderate. Oxycodone and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel can cause dizziness, somnolence and impaired coordination, which may add to opioid CNS effects. Perampanel also has weak CYP3A4 induction at higher doses, which might modestly lower oxycodone levels.
How serious is the interaction between Oxycodone and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and falls, and check analgesic response, adjusting the oxycodone dose if necessary.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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