Drug interactions
Oxycodone + Tasimelteon
Severity: Minor
Oxycodone and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon may cause somnolence and could add modestly to opioid-related sedation. Significant respiratory depression is not an established concern with tasimelteon.
What this interaction means in plain words
Oxycodone and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxycodone belongs to Musculoskeletal; Tasimelteon belongs to Central Nervous System.
Why it happens
Additive mild CNS depressant effects from melatonin receptor agonism and opioid activity.
What to do
Counsel patients about additive drowsiness and avoid driving until response is known. No dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Tasimelteon
Frequently asked questions
Can I take Oxycodone with Tasimelteon?
MediHelp rates the interaction as minor. Oxycodone and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon may cause somnolence and could add modestly to opioid-related sedation. Significant respiratory depression is not an established concern with tasimelteon.
How serious is the interaction between Oxycodone and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving until response is known. No dose change is routinely needed.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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