Drug interactions
Oxycodone + Vilazodone
Severity: Moderate
Oxycodone and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a serotonergic antidepressant can rarely cause serotonin syndrome, with agitation, tremor, hyperreflexia, clonus, fever and autonomic instability. Oxycodone has weak serotonergic activity, so the risk is lower than with agents such as tramadol or meperidine, but it is recognized in labeling.
What this interaction means in plain words
Oxycodone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from vilazodone (SSRI and 5-HT1A partial agonist) and oxycodone.
What to do
Use the lowest effective doses and monitor for signs of serotonin syndrome, especially at initiation or dose increases. Stop both agents and treat supportively if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Oxycodone with Vilazodone?
MediHelp rates the interaction as moderate. Oxycodone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with a serotonergic antidepressant can rarely cause serotonin syndrome, with agitation, tremor, hyperreflexia, clonus, fever and autonomic instability. Oxycodone has weak serotonergic activity, so the risk is lower than with agents such as tramadol or meperidine, but it is recognized in labeling.
How serious is the interaction between Oxycodone and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for signs of serotonin syndrome, especially at initiation or dose increases. Stop both agents and treat supportively if symptoms appear.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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