Drug interactions
Pacritinib + Temsirolimus
Severity: Moderate
Pacritinib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib inhibits P-glycoprotein and could increase temsirolimus exposure. This may increase mTOR inhibitor adverse effects such as mucositis, cytopenias and infection.
What this interaction means in plain words
Pacritinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pacritinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Inhibition of P-gp efflux, reducing temsirolimus elimination.
What to do
Monitor for temsirolimus toxicity and blood counts; consider a temsirolimus dose reduction if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Temsirolimus?
MediHelp rates the interaction as moderate. Pacritinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib inhibits P-glycoprotein and could increase temsirolimus exposure. This may increase mTOR inhibitor adverse effects such as mucositis, cytopenias and infection.
How serious is the interaction between Pacritinib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity and blood counts; consider a temsirolimus dose reduction if adverse effects emerge.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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