Drug interactions
Palbociclib + Posaconazole
Severity: Major
Palbociclib and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases palbociclib exposure, which may worsen neutropenia and other myelosuppression. The effect is expected from palbociclib's CYP3A-dependent clearance.
What this interaction means in plain words
Palbociclib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palbociclib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, reducing palbociclib metabolism.
What to do
Prefer an alternative antifungal. If unavoidable, reduce palbociclib to 75 mg daily per labeling and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Posaconazole?
MediHelp rates the interaction as major. Palbociclib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole increases palbociclib exposure, which may worsen neutropenia and other myelosuppression. The effect is expected from palbociclib's CYP3A-dependent clearance.
How serious is the interaction between Palbociclib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antifungal. If unavoidable, reduce palbociclib to 75 mg daily per labeling and monitor blood counts closely.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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