Drug interactions
Pentamidine + Sevoflurane
Severity: Major
Pentamidine and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine, especially intravenously, can cause QT prolongation, torsades de pointes and hypotension. Sevoflurane can add to the QT effect and to hypotension.
What this interaction means in plain words
Pentamidine and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pentamidine belongs to Anti Parasitic; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the ECG and blood glucose and blood pressure during the procedure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Pentamidine with Sevoflurane?
MediHelp rates the interaction as major. Pentamidine and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentamidine, especially intravenously, can cause QT prolongation, torsades de pointes and hypotension. Sevoflurane can add to the QT effect and to hypotension.
How serious is the interaction between Pentamidine and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the ECG and blood glucose and blood pressure during the procedure.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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