Drug interactions
Pentamidine + Tiotropium-olodaterol
Severity: Moderate
Pentamidine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine, particularly when given intravenously, can prolong the QT interval and cause torsades de pointes and dysglycemia. Beta2 agonists may add to the arrhythmia risk via tachycardia and hypokalemia.
What this interaction means in plain words
Pentamidine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pentamidine belongs to Anti Parasitic; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and sympathetic stimulation.
What to do
Monitor ECG and keep potassium and magnesium within normal range during systemic pentamidine therapy. Reassess the need for the beta agonist if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Pentamidine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Pentamidine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine, particularly when given intravenously, can prolong the QT interval and cause torsades de pointes and dysglycemia. Beta2 agonists may add to the arrhythmia risk via tachycardia and hypokalemia.
How serious is the interaction between Pentamidine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal range during systemic pentamidine therapy. Reassess the need for the beta agonist if QTc lengthens.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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