Drug interactions
Pentamidine + Trazodone
Severity: Major
Pentamidine and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can prolong the QT interval and cause torsades de pointes, and trazodone adds to this effect. Arrhythmia risk is higher with electrolyte disturbances.
What this interaction means in plain words
Pentamidine and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pentamidine belongs to Anti Parasitic; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Avoid if possible. If both are required, check ECG and potassium and magnesium before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Pentamidine with Trazodone?
MediHelp rates the interaction as major. Pentamidine and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentamidine can prolong the QT interval and cause torsades de pointes, and trazodone adds to this effect. Arrhythmia risk is higher with electrolyte disturbances.
How serious is the interaction between Pentamidine and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If both are required, check ECG and potassium and magnesium before and during treatment.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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