Drug interactions
Perphenazine + Porfimer
Severity: Moderate
Perphenazine and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Porfimer is a photosensitizer used in photodynamic therapy, and phenothiazines like perphenazine are themselves photosensitizing. Combined use may increase the severity or duration of skin photosensitivity reactions.
What this interaction means in plain words
Perphenazine and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects.
What to do
Reinforce strict avoidance of sunlight and bright indoor light after porfimer, and consider whether perphenazine can be held. Inspect the skin and eyes for phototoxic reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Porfimer
Frequently asked questions
Can I take Perphenazine with Porfimer?
MediHelp rates the interaction as moderate. Perphenazine and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Porfimer is a photosensitizer used in photodynamic therapy, and phenothiazines like perphenazine are themselves photosensitizing. Combined use may increase the severity or duration of skin photosensitivity reactions.
How serious is the interaction between Perphenazine and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reinforce strict avoidance of sunlight and bright indoor light after porfimer, and consider whether perphenazine can be held. Inspect the skin and eyes for phototoxic reactions.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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