Drug interactions
Perphenazine + Rolapitant
Severity: Moderate
Perphenazine and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is largely cleared by CYP2D6, and rolapitant inhibits this enzyme for weeks. Higher perphenazine levels may cause extrapyramidal symptoms, sedation, hypotension and QT prolongation.
What this interaction means in plain words
Perphenazine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, decreasing perphenazine clearance.
What to do
Monitor for extrapyramidal and sedative effects, and consider a lower perphenazine dose. Obtain an ECG if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Rolapitant?
MediHelp rates the interaction as moderate. Perphenazine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is largely cleared by CYP2D6, and rolapitant inhibits this enzyme for weeks. Higher perphenazine levels may cause extrapyramidal symptoms, sedation, hypotension and QT prolongation.
How serious is the interaction between Perphenazine and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal and sedative effects, and consider a lower perphenazine dose. Obtain an ECG if QT risk factors are present.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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