Drug interactions
Polatuzumab vedotin + Posaconazole
Severity: Moderate
Polatuzumab vedotin and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase exposure to the cytotoxic payload MMAE released from polatuzumab vedotin, potentially worsening neutropenia and peripheral neuropathy. The expected effect is on unconjugated MMAE rather than the antibody conjugate.
What this interaction means in plain words
Polatuzumab vedotin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Polatuzumab vedotin belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, which metabolizes MMAE.
What to do
Monitor blood counts and neuropathy symptoms more closely during coadministration and delay or modify dosing if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Polatuzumab vedotin with Posaconazole?
MediHelp rates the interaction as moderate. Polatuzumab vedotin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase exposure to the cytotoxic payload MMAE released from polatuzumab vedotin, potentially worsening neutropenia and peripheral neuropathy. The expected effect is on unconjugated MMAE rather than the antibody conjugate.
How serious is the interaction between Polatuzumab vedotin and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms more closely during coadministration and delay or modify dosing if toxicity develops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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