Drug interactions
Posaconazole + Risperidone
Severity: Moderate
Posaconazole and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have the potential to prolong the QT interval, and posaconazole may modestly increase risperidone exposure. The combination may increase the risk of ventricular arrhythmias, especially in patients with other risk factors.
What this interaction means in plain words
Posaconazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus CYP3A4 and P-glycoprotein inhibition by posaconazole reducing risperidone clearance.
What to do
Check ECG and electrolytes at baseline and during co-therapy, and reduce the risperidone dose if adverse effects or QTc lengthening develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Posaconazole with Risperidone?
MediHelp rates the interaction as moderate. Posaconazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have the potential to prolong the QT interval, and posaconazole may modestly increase risperidone exposure. The combination may increase the risk of ventricular arrhythmias, especially in patients with other risk factors.
How serious is the interaction between Posaconazole and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during co-therapy, and reduce the risperidone dose if adverse effects or QTc lengthening develop.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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