Drug interactions
Posaconazole + Ruxolitinib
Severity: Moderate
Posaconazole and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises ruxolitinib exposure, which can enhance myelosuppression such as thrombocytopenia, anemia and neutropenia.
What this interaction means in plain words
Posaconazole and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Ruxolitinib belongs to Oncology.
Why it happens
Posaconazole inhibits CYP3A4, the main metabolic pathway of ruxolitinib.
What to do
Reduce ruxolitinib dose per labeling when using strong CYP3A4 inhibitors and monitor blood counts frequently, adjusting the dose to response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Posaconazole with Ruxolitinib?
MediHelp rates the interaction as moderate. Posaconazole and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole raises ruxolitinib exposure, which can enhance myelosuppression such as thrombocytopenia, anemia and neutropenia.
How serious is the interaction between Posaconazole and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce ruxolitinib dose per labeling when using strong CYP3A4 inhibitors and monitor blood counts frequently, adjusting the dose to response and toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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