Drug interactions
Posaconazole + Stiripentol
Severity: Moderate
Posaconazole and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is metabolized by several CYP enzymes including CYP3A4, so posaconazole may increase its levels. Higher exposure may worsen sedation and other adverse effects.
What this interaction means in plain words
Posaconazole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Stiripentol belongs to Central Nervous System.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of stiripentol.
What to do
Monitor for sedation, ataxia and other adverse effects and reduce the stiripentol dose if they occur. Consider an alternative antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Posaconazole with Stiripentol?
MediHelp rates the interaction as moderate. Posaconazole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is metabolized by several CYP enzymes including CYP3A4, so posaconazole may increase its levels. Higher exposure may worsen sedation and other adverse effects.
How serious is the interaction between Posaconazole and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and other adverse effects and reduce the stiripentol dose if they occur. Consider an alternative antifungal.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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