Drug interactions
Posaconazole + Tiotropium-olodaterol
Severity: Moderate
Posaconazole and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can prolong the QT interval, and olodaterol may add to this through beta2-mediated hypokalemia and sympathetic stimulation. The combination may increase the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Posaconazole and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-induced hypokalemia.
What to do
Check potassium and magnesium and correct deficits. Monitor the ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Posaconazole and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can prolong the QT interval, and olodaterol may add to this through beta2-mediated hypokalemia and sympathetic stimulation. The combination may increase the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Posaconazole and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits. Monitor the ECG in patients with other QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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