Drug interactions
Posaconazole + Trimipramine
Severity: Major
Posaconazole and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise trimipramine concentrations, and both drugs can prolong the QT interval. This increases the risk of arrhythmia and tricyclic toxicity such as sedation and anticholinergic effects.
What this interaction means in plain words
Posaconazole and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Posaconazole belongs to Anti Fungals; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with CYP3A4 inhibition by posaconazole reducing trimipramine metabolism.
What to do
Avoid if possible; otherwise obtain a baseline and follow-up ECG, correct electrolytes, and consider reducing the trimipramine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Posaconazole with Trimipramine?
MediHelp rates the interaction as major. Posaconazole and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole may raise trimipramine concentrations, and both drugs can prolong the QT interval. This increases the risk of arrhythmia and tricyclic toxicity such as sedation and anticholinergic effects.
How serious is the interaction between Posaconazole and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain a baseline and follow-up ECG, correct electrolytes, and consider reducing the trimipramine dose.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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