Drug interactions
Posaconazole + Zonisamide
Severity: Minor
Posaconazole and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is partly metabolised by CYP3A4, so posaconazole may increase its concentrations. This could cause more dizziness, somnolence, cognitive slowing or metabolic acidosis.
What this interaction means in plain words
Posaconazole and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Posaconazole belongs to Anti Fungals; Zonisamide belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 reduces zonisamide clearance.
What to do
No routine dose change; monitor for CNS adverse effects and consider checking zonisamide levels if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Posaconazole with Zonisamide?
MediHelp rates the interaction as minor. Posaconazole and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zonisamide is partly metabolised by CYP3A4, so posaconazole may increase its concentrations. This could cause more dizziness, somnolence, cognitive slowing or metabolic acidosis.
How serious is the interaction between Posaconazole and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for CNS adverse effects and consider checking zonisamide levels if toxicity is suspected.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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