Drug interactions
Pregabalin + Tasimelteon
Severity: Minor
Pregabalin and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon is a melatonin receptor agonist with mild sedating effects, and pregabalin can add to drowsiness and dizziness. A clinically important interaction is not well documented and the expected effect is small.
What this interaction means in plain words
Pregabalin and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pregabalin belongs to Central Nervous System; Tasimelteon belongs to Central Nervous System.
Why it happens
Possible additive mild CNS depression.
What to do
Monitor for daytime drowsiness and dizziness when the two are started together. Advise caution with driving if sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pregabalin
Other interactions of Tasimelteon
Frequently asked questions
Can I take Pregabalin with Tasimelteon?
MediHelp rates the interaction as minor. Pregabalin and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon is a melatonin receptor agonist with mild sedating effects, and pregabalin can add to drowsiness and dizziness. A clinically important interaction is not well documented and the expected effect is small.
How serious is the interaction between Pregabalin and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime drowsiness and dizziness when the two are started together. Advise caution with driving if sedation occurs.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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