Drug interactions
Pregabalin + Vilazodone
Severity: Moderate
Pregabalin and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin commonly causes somnolence, dizziness and cognitive slowing, and respiratory depression has been reported when combined with other CNS depressants. Combined with vilazodone, additive sedation and psychomotor impairment may occur.
What this interaction means in plain words
Pregabalin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pregabalin belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects (pharmacodynamic).
What to do
Use the lowest effective pregabalin dose and titrate gradually, monitoring for sedation and respiratory depression. Warn patients about driving and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pregabalin and Vilazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Pregabalin with Vilazodone?
MediHelp rates the interaction as moderate. Pregabalin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin commonly causes somnolence, dizziness and cognitive slowing, and respiratory depression has been reported when combined with other CNS depressants. Combined with vilazodone, additive sedation and psychomotor impairment may occur.
How serious is the interaction between Pregabalin and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pregabalin dose and titrate gradually, monitoring for sedation and respiratory depression. Warn patients about driving and avoid alcohol.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
